The heterotetradimers are fashioned next the interaction of UPK2 and UPK3A moieties of your heterodimers. Following assembly in the endoplasmic reticulum as well as Golgi, 6 heterotetradimers arranged in inner and outer rings68 sort a sixteen?nm AUM particle or plaque (Fig. 3), packaged into DFVs and delivered to the apical membrane69. The AUM par